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View this article with LENS. Prev Next Table of Contents. This Article First Published on January 28, doi: Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLK , acts in the epidermis to promote the terminal differentiation of human keratinocytes. Classifications Mechanisms of Signal Transduction.

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Classifications Mechanisms of Signal Transduction.

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Search for related content. Articles by Germain, L. Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification.

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In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. Google Scholar Xlk by Robitaille, H.

This Article First Published on January 28, doi: In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.

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View this article with LENS. To whom correspondence may be addressed: You’ll be in good company.

In addition, cultured keratinocytes infected with a recombinant adenovirus expressing Dl exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.

Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not.

Prev Next Table of Contents. Services Email this article to a friend Alert me when this article is cited Alert me if 800 correction is posted Alert dok when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions.

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Submit your work to JBC. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined.

Journal of Lipid Research. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human 8000. Related Content Load related web page information.